Political Heir Says Too Few in India Hold Political Sway





NEW DELHI — Rahul Gandhi is a member of a family that has led India for most of the nation’s 65-year history, but in one of the most important speeches of his life on Sunday he was deeply critical of the Indian government.




“No matter what state you look at, no matter which political party you look at, why do a handful of people control the entire political space?” Mr. Gandhi asked. “Power is grossly centralized in our country.”


Indeed, power in India has mostly been centralized in Mr. Gandhi’s family, and his speech on Sunday was his first major step in trying to ensure that this centralization continues well past 2014, when national elections are scheduled. Mr. Gandhi is the son, grandson and great-grandson of previous Indian prime ministers. He and his mother, Sonia Gandhi, president of the Indian National Congress Party, gave speeches on Sunday on the last day of a party meeting in Jaipur.


“And it does not matter how much wisdom you have, you mean nothing,” Mr. Gandhi said. “This is the tragedy of India. Why is our youth angry? Why are they out on the street? They are angry because they are alienated. They are excluded from the political class.” Mr. Gandhi said the entire system must be transformed, although he said that the Congress Party had already begun that process.


He was formally elevated Saturday to vice president in the governing Congress Party, making him second only to his mother in the party’s hierarchy. His promotion has been years in the making, and many in the party have been quietly pressing him to take a more active role in governing for years. He has never held a cabinet-level position.


In her own remarks, Mrs. Gandhi turned to a recent crime that prompted widespread outrage. “The barbaric gang-rape of a young woman in Delhi has shaken the country, she said. “She embodied the spirit of an aspirational India. We will ensure her death will not go in vain.”


She promised to press for legislation to ensure that 30 percent of the positions in Parliament and the state legislative assemblies would be held by women. India has a vast system of quotas for the historically disadvantaged, and expanding those set-asides has for years been deeply popular with those who benefit from them — which increasingly is much of the population.


Mrs. Gandhi also said that the Congress Party needed to do a better job of explaining its successes, and she lashed out at corruption as “a deep-rooted malice.”


“As a party we must lead the struggle to combat its effect,” she said.


The Gandhi family has long been the glue that held the Congress Party together even as regional rivals have become more powerful. Sonia Gandhi has mostly carried the Gandhi mantel since her husband, Prime Minister Rajiv Gandhi, was assassinated. But she is a native of Italy, and when her party won the 2004 elections, she chose a technocrat, Manmohan Singh, to be the government’s prime minister.


But Mr. Singh is 80. Few expect him to continue as prime minister past next year, and many in the party have looked to Mr. Gandhi to take up his role as the leader of his family and his party.


Whether Mr. Gandhi will thrive in this role is a source of constant speculation. He entered politics in 2004 by taking over a seat in Parliament vacated for him by his mother, who moved to a neighboring constituency. He campaigned aggressively in recent state elections in Uttar Pradesh and Bihar, but his party was soundly defeated in both places. Perhaps wary of another poor performance, he and his mother campaigned sparingly in December during state elections in Gujarat, where the Congress Party was again defeated.


It is still unclear whether Mr. Gandhi will be tapped as the party’s pick for prime minister next year. Equally uncertain is who will be the candidate for the Bharatiya Janata Party, the main opposition. Narendra Modi is now that party’s most accomplished leader, but he is deeply unpopular with Muslims because he was in charge in Gujarat when deadly riots erupted there in 2002, leaving nearly 1,000 people dead, many of them Muslims.


Mr. Gandhi has led party youth organizations, and Congress Party leaders hope he will be able to appeal to India’s vast youth population. At 42, he is much younger than most of India’s leaders, whose average age is 65.


Hari Kumar contributed reporting.



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BlackBerry Z10 confirmed for Verizon in new leak







Another day, another handful of BlackBerry 10 leaks to enjoy as the tech world waits for the new platform’s January 30th unveiling. Twitter user “evleaks,” who has a solid track record of leaking accurate details and images of unreleased smartphones, published a purported screenshot from Verizon Wireless (VZ) on Friday. The document confirms some details we already know — RIM’s (RIMM) first full-touch BlackBerry 10 phone will be called the BlackBerry Z10 and will feature 4G LTE, among other specs — and it also confirms Verizon will support the handset. An image of Verizon’s BlackBerry Z10 screenshot follows below.


[More from BGR: Samsung’s latest monster smartphone will reportedly have a 5.8-inch screen]






This article was originally published on BGR.com


Gadgets News Headlines – Yahoo! News





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Five Things to Know About The Lumineers















01/19/2013 at 06:00 PM EST







From left: Wesley Schultz, Neyla Pekarek and Jeremiah Fraites


Alan Poizner/PictureGroup


You already know their hit song "Ho Hey" with its catchy shout-it-out chant that sticks in your head – but what's behind Denver-based band The Lumineers' cool blend of indie rock and Americana?

Here are five things to know about the trio – Wesley Schultz (lead vocals, guitar), 30; Jeremiah Fraites (guitar), 27; and Neyla Pekarek (cello, piano), 26 – who are up for two Grammys (best new artist and best Americana album) and are also performing on Saturday Night Live this week alongside host Jennifer Lawrence.

1. Most people think that 'Ho Hey' – which reached No. 1 on three different charts – is about a romantic relationship, but that's not the whole story.
"The essence of the song was that I was really struggling to make ends meet in the big city when I was living in Brooklyn and working in New York. It was a myth, this idea that you'd go there and get discovered and it would be this great place for music," explains Schultz, who, like Fraites, hails from New Jersey and moved to Denver in recent years, where they met Pekarek.

"It's about a lost love in some ways, but it's also a lost dream. It's funny that a lot of people play it at their weddings because it was written from a different place. But it's kind of a beautiful thing, actually, that people can take something I was feeling really, really down about and turn it into a message of hope."

2. They've only recently been able to quit their day jobs.
"I was working as a busser, a bartender, a barista, a guitar teacher, caterer – a lot of service industry jobs, because it allows you to get away and tour if you need to or take a night off to play," explains Schultz.

"Jer was bussing tables right along beside me. And Neyla was a hostess and a substitute teacher. She'd been offered a full-time teaching position while we were in the midst of touring – and losing a lot of money – and she still stuck with it. Somehow she chose this over that, which is absurd, but we're glad she did!"

3. They named their hit song carefully.
Were they ever concerned people might call it "Hey Ho" in a derogatory way? "Yeah, at some point we laughed about it," says Schultz. "We specifically named it 'Ho Hey' instead of 'Hey Ho' [for that reason]. If people searched for it online, we'd rather it not be something that takes you in that direction."

Do they mind when people get the title wrong? "Oh no, that would be a little pretentious!" says Schultz with a chuckle. "It's kind of a silly name to begin with."

4. That's Schultz's mom on the cover of their debut, self-titled album.
"It's my mom, Judy, as a child, and her mother," he explains. "I'd asked my mom if she had any old photos that I could look through a while back, and I fell in love with it. You know if you set up a child for a picture then can't get out of the frame in time? My mom had a funny take on it: It's our first album, kind of our baby, like this child."

Schultz thanked his mom for all her years of emotional support with some heavy metal when their album went gold. "I had the plaque sent to my mom, because she'd been really supportive of us and believed in us when a lot of people were pretty concerned. And now she's got a platinum one!"

5. Their band name has more than one meaning.
While Schultz and Fraites have been playing music together for more than eight years (previous band names include Free Beer, 6Cheek, and Wesley Jeremiah), they've only been known as The Lumineers for the last four thanks to a mistake.

"We were playing a small club in Jersey City, N.J.," explains Schultz, "and there was a band out there at the time called Lumineers who were slotted for the same time, same day, the next week. The person running the show that night [mistakenly] announced us as The Lumineers."

The name stuck. "It doesn't mean anything literally. It's a made-up word," says Schultz. Another strange coincidence they learned? "It's also the name of a dental veneer company," he adds.

So how are Schultz's teeth? "I have a pretty good smile," he says with a big laugh. "I won 'Best Smile' in high school. It's a pretty big deal."

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Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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News Analysis: Hollande’s Intervention in Mali Raises Concerns


Fred Dufour/Agence France-Presse — Getty Images


Malian Army soldiers ran a checkpoint in Niono on Friday. Officials said that 1,800 French troops were in Mali, with more coming.





In just two hours last Thursday, after a plea for help from Mali’s interim president, Dioncounda Traoré, Mr. Hollande decided to send in French warplanes and ground troops.


It was supposed to be a quick and dramatic blow that would send the Islamists scurrying back to their hide-outs in northern Mali, buying time for the deployment of an African force to stabilize the situation. Instead it is turning into what looks like a complex and drawn-out military and diplomatic operation that Mr. Hollande’s critics are already calling a desert version of a quagmire, like Vietnam or Afghanistan.


Some here speak of Mr. Hollande’s “Sahelistan.” Valéry Giscard d’Estaing, the former French president, reminded Mr. Hollande of “the danger of a military operation without a clear enemy, with the risk to civilians that is bound to engender hostility among the citizens.” He warned of “neocolonialism.”


Mr. Hollande, who has a reputation for indecisiveness, has certainly taken on a difficult task. The French are fighting to preserve the integrity of a country that is divided in half, of a state that is broken. They are fighting for the survival of an interim government with no democratic legitimacy that took power in the aftermath of a coup.


But Mr. Traoré, 70, does represent the internationally recognized government of Mali, said a senior French official, shrugging. And then, like every French official on the topic, he asked a questioner to imagine the alternative — “another Somalia” on the western edge of Africa, lawless and dominated by Islamic radicals close to Al Qaeda in the Islamic Maghreb, who would set about instituting the harshness of Shariah law all over Mali, stoning adulterers and cutting off the hands of thieves, while engaging in the drug and arms smuggling, kidnapping and terrorism that funds their notion of jihad.


That prospect, the officials insist, is why the entire region, including Algeria, has supported the French intervention, which was also backed by the Security Council. The French initiative has also had public support, if provoking quiet concern about overreaching, from allies like the United States and Britain.


It was not supposed to be this way, French officials and experts acknowledge. Sometime in the autumn, under United Nations Security Council Resolution 2085, African troops from the Economic Community of West African States, or Ecowas, together with a retrained and reinspired Malian Army, were supposed to take back the north of the country. Those African forces were to be trained with the help of the European Union and guided in their mission by French forces in an advisory capacity, with the United States helping to provide financing and airborne reconnaissance, intelligence, air transport and air-to-air refueling.


France was supposed to have a largely civilian role, not itself engaged in fighting and with no troops on the ground. Ecowas and the Malians were supposed to fight their way into northern Mali and clear it of Islamists.


Just 10 days ago, before Mr. Hollande’s sudden action, a senior adviser at the Élysée described how slowly the Mali operation was going. He described the difficulties with Ecowas, with squabbles over financing, training and transporting Ecowas troops, and how hard it had been to get Washington, after the Libyan civil war, to pay attention to a deteriorating situation in Mali and the risks of Islamic terrorism spreading in the Sahel.


The Americans finally started listening to French concerns last September, he said, but had their doubts about how easy it would be to drive the Islamists out of the vastness of northern Mali. And Washington did not consider the Ecowas plan to be well conceived.


The Islamist rebels chose not to wait around, of course, launching their push to the south and prompting French intervention in a singularly leading role. With 1,800 troops now in Mali and a projected total of 2,500, the French do not need help on the ground, officials insist. But they are pushing Washington to move more quickly through the interagency process to provide reconnaissance drones, air transport planes and refueling planes. European and NATO allies like Britain have already moved to help, with the British quickly providing two C-17 transport planes to move troops and equipment.


On Friday, Prime Minister David Cameron of Britain gave explicit support to France and an implicit push to Washington and European allies to do more in West Africa to fight radical Islamic terrorism. “Those who believe that there is a terrorist, extremist Al Qaeda problem in parts of North Africa, but that it is a problem for those places and we can somehow back off and ignore it, are profoundly wrong,” he told Parliament.


John F. Burns contributed reporting from London.



This article has been revised to reflect the following correction:

Correction: January 19, 2013

An earlier version of the caption with the picture atop this article misspelled the name of the Malian town where soldiers were monitoring a checkpoint. It is Niono, not Nioni.



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America’s national parks weigh solitude against cellular access






SALMON, Idaho (Reuters) – As cell phones, iPods and laptops creep steadily into every corner of modern life, America’s national parks have stayed largely off the digital grid, among the last remaining outposts of ringtone-free human solitude.


For better or worse, that may soon change.






Under pressure from telecommunications companies and a growing number of park visitors who feel adrift without mobile-phone reception, the airwaves in such grand getaway destinations as Yellowstone National Park may soon be abuzz with new wireless signals.


That prospect has given pause to a more traditional cohort of park visitors who cherish the unplugged tranquility of the great outdoors, fearing an intrusion of mobile phones – and the sound of idle chatter – will diminish their experience.


Some have mixed emotions. Stephanie Smith, a 50-something Montana native who visits Yellowstone as many as six times a year, said she prefers the cry of an eagle to ring tones.


But she also worries that future generations may lose their appreciation for the value of nature and the need to preserve America’s outdoor heritage if a lack of technology discourages them from visiting.


“You have to get there to appreciate it,” Smith said. “It’s a new world – and technology is a part of it.”


Balancing the two aesthetics has emerged as the latest challenge facing the National Park Service as managers in at least two premier parks, Yellowstone and Glacier national parks, consider recent requests to install new telecommunications towers or upgrade existing ones.


There is no system-wide rule governing cellular facilities in the 300 national parks, national monuments and other units the agency administers nationwide. Wireless infrastructure decisions are left up to the managers of individual park units.


The agency’s mission statement requires it to protect park resources and the visitor experience, but each individual experience is unique, said Lee Dickinson, a special-uses program manager for the Park Service.


“I’ve had two visitors calling me literally within hours of each other who wanted exactly the opposite experience: One saying he didn’t vacation anywhere without electronic access and the other complaining he was disturbed by another park visitor ordering pizza on his cell phone,” Dickinson said.


CAN YOU HEAR ME NOW?


Wireless supporters say more is at stake than the convenience of casual phone conversations. Cellular providers say new wireless infrastructure will boost public safety by improving communications among park rangers and emergency responders.


They argue that the ability to download smartphone applications that can deliver instant information on plants and animals will also enrich park visitors’ experiences.


“Our customers are telling us that having access to technology will enhance their visit to wild areas,” said Bob Kelley, spokesman for Verizon Wireless, which is seeking to install a new 100-foot cell tower at Yellowstone.


Rural communities that border the national parks also stand to benefit from enlarged cellular coverage areas.


On the other side of the debate, outdoor enthusiasts worry that bastions of quiet reflection could be transformed into noisy hubs where visitors yak on cell phones and fidget with electronic tablets, detracting from the ambience of such natural wonders as Yellowstone’s celebrated geyser Old Faithful.


Expanding cellular reception may even compromise safety by giving some tourists a false sense of security in the back country, where extremes in weather and terrain test even the most skilled outdoorsman, according to the National Parks Conservation Association.


Tim Stevens, the association’s Northern Rockies director, said distractions like meandering moose already challenge the attention of motorists clogging park roads at the height of the summer tourist season.


“People brake in the middle of the road to watch animals. The added distraction of a wireless signal – allowing a driver to text Aunt Madge to say how great the trip is – could have disastrous consequences,” he said.


Yellowstone already offers some limited mobile-phone service, afforded by four cellular towers previously erected in developed sections of the park.


But vast swathes of America’s oldest national park, which spans nearly 3,500 square miles across the states of Wyoming, Montana and Idaho, still lack wireless reception in an age dominated by Wi-Fi and iPad users who expect access even in the most remote locations.


Park officials see definite signs that a portion of the roughly 3 million annual visitors to Yellowstone, which crafted a wireless plan in 2008, are finding the lack of cell phone coverage disconcerting.


Park spokesman Al Nash said he routinely fields calls from anxious relatives of Yellowstone visitors unable to contact their loved ones.


“They say, ‘My gosh, my niece, daughter or parents went to Yellowstone, and we haven’t heard from them for three days,’” he said.


(Reporting and writing by Laura Zuckerman; Editing by Steve Gorman and David Gregorio)


Gadgets News Headlines – Yahoo! News





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Marla Sokoloff Blogs: Adventures in Baby Traveling

Marla Sokoloff's Blog: Adventures in Baby Traveling
Shady ladies in Hawaii – Courtesy Marla Sokoloff


Our celebrity blogger Marla Sokoloff is a new mama!


Since audiences first got to know her at age 12 as Gia on Full House, Sokoloff has had many memorable TV roles — Jody on Party of Five, Lucy on The Practice, Claire on Desperate Housewives – as well as turns on the big screen in Whatever It Takes, Dude, Where’s My Car? and Sugar & Spice.


Sokoloff, 32, also sings and plays guitar and released an album, Grateful, in 2005.


She wed her husband, music composer Alec Puro, in November 2009 and the couple — plus pup Coco Puro — make their home in Los Angeles.


You can find Marla, now mom to 11-month-old daughter Elliotte Anne, on Twitter.


Happy 2013! I don’t know about you, but I’m completely amazed at how fast 2012 flew by! I must admit, on New Year’s Day I found myself a little weepy to say goodbye to the year that my little Elliotte came into this world. I realized that as long as I’m on this earth I will always have a soft spot for the year 2012, as it was a complete life and game-changer for me. (Clearly it’s also the year that turned me into a total sap!)


As far as resolutions go, I have a few. They include the usual suspects (exercise more, get more sleep, drink more than four sips of water per day!) but my main focus is going to be on my beloved iPhone and our very dysfunctional relationship.


I really want to work on being in the present and putting that thing down so I can suck up every delicious moment with my family. The social media and pinboards will just have to wait until after my daughter goes to bed. Baby steps!


Last week we hit a huge milestone … Elliotte took her first steps and is now walking (albeit a bit drunk-like) almost on her own! The moment was truly unbelievable and one that left me in tears (shocking … I know) as I was simply overwhelmed with joy. I was just so proud of her.


This is where my resolution isn’t a good thing because — had I not had my trusty iPhone glued to my body — I might have missed the moment. Her grandparents would have killed me! I’m just saying…


Marla Sokoloff's Blog: Adventures in Baby Traveling
Happy New Year! – Courtesy Marla Sokoloff


We spent our Christmas vacation in paradise on the Big Island of Hawaii, but I’m here to tell you that getting there was nothing short of a nightmare. I’m not going to lie or candy-coat this blog at all because this experience was one I never want to relive.


All of my friends warned me about baby airplane travel … basically it could go either way. Kids are wild cards and you never really know what you’re going to get. So in preparation for my little wild card, I boarded our flight armed with earplugs and chocolates for the innocent passengers that could potentially be caught in the line of fire, so to speak. All the while knowing that I will never need to bring out said earplugs … I mean, my child is perfect after all!


This wasn’t Elliotte’s first flight — over the summer we traveled to San Francisco and my little angel slept for the hour flight each way, so I was certain we had this Hawaiian excursion in the bag.


I came equipped with two giant diaper bags. One was filled with diaper bag essentials (diapers, wipes, pacifiers, bottles, change of clothes for both of us) and the other ridiculously large bag was filled with toys and snacks. So many toys and snacks!! If this plane went down, Elliotte could feed the whole cabin with her copious supply of puffs and Cheerios. Basically the plan was, if this kid wasn’t sleeping, I was going to keep her busy and well-fed!


My special edition diaper bag also contained an emergency item. An SOS of sorts. An article that is generally considered a baby no-no in my house, but one that was only to be revealed if absolutely 100 percent necessary. Friends, I’m talking about the iPad. I loaded my secret weapon up with episodes of Sesame Street and adorable farm animal applications that looked like they would keep Elliotte entertained for at least a temper tantrum or two.


Very much like the aforementioned earplugs, I felt pretty confident that our no-no item wouldn’t be making an appearance.


Marla Sokoloff's Blog: Adventures in Baby Traveling
Before takeoff… – Courtesy Marla Sokoloff


As our flight took off, I could see that Elliotte was not the happy camper I know and love. Her face turned beet-red within seconds and she was thrashing in her carseat as if it was a torture device. The tears were flowing fast and her scream was one that could not be silenced.


I looked at my husband, whose eyes said, “Bring out the iPad!!” but I knew it was way too early in our journey to pull such tricks out of sleeves.


As Alec handed out the chocolate and earplugs to our unlucky neighbors, I brought out some of Elliotte’s favorite toys. Every toy that was presented was met with a louder scream. I moved on to my trusted stash of snacks — surely a handful of puffs would soothe this outburst. Fail. I sang. I danced. I peek-a-booed. Nothing.


How can this be? The seat belt sign hasn’t even been turned off yet and I have pretty much emptied out the contents of my special-edition diaper bag!


Once the captain decided to put me out of my misery and turned the seat belt sign off, I ripped Elliotte out of her carseat (the one I brought thinking she would sleep in) and decided a nice walk down the aisle would do us both some good.


That mission was quickly aborted as the scream-fest continued to unaffected rows that were surely enjoying their cocktails and weekly gossip magazines.


Marla Sokoloff's Blog: Adventures in Baby Traveling
My beach baby in Hawaii – Courtesy Marla Sokoloff


I handed her off to my husband and I took a much-needed break, as well as the first deep breath I had taken since leaving Los Angeles International Airport. We were now three-and-a-half hours into our six-hour flight and Elliotte showed no signs of slowing down. It was in this moment that I turned to my family and saw the chaos.


My seat was littered with toys and Cheerios and my poor child looked like a complete mess. Her face was tear-stained and her clothes were covered in squeezable applesauce. (Another failed mission.)


I knew it was time to bring out the big guns. Elmo needed to step in and he better be bringing his A-game.


I placed Elliotte on my lap and out came the iPad. Images of all of my favorite characters appeared on the screen and I instantly felt comforted by my childhood friends. Not only because they are the same characters that were my source of calm as a child, but also I knew they were the lifesavers we so desperately needed.


Well … I guess iPads and big yellow birds aren’t that comforting to teething babies that are 30,000 feet up in the air. The iPad went flying and I sunk into my seat holding my very unhappy girl tight. I was officially out of ideas.


Marla Sokoloff's Blog: Adventures in Baby Traveling
Hawaiian fun in the sun – Courtesy Marla Sokoloff


A kind woman in front of me asked to hold Elliotte. She saw in my eyes that I was breaking down and she was a mom who got it. She understood. She didn’t judge or hate us for disrupting the beginning of her holiday vacation — she was happy to help because she had once been in our shoes with her own child. Elliotte enjoyed the break from her parents and was actually smiling in her arms.


We finally arrived in paradise and upon landing, Alec and I decided that we were moving to Hawaii as we were never going to step foot on a plane ever again.


In all fairness, in between Thanksgiving and Christmas, Elliotte went from having two teeth to eight teeth so I think the plane and cabin pressure exacerbated any existing pain she was already having. Our journey home was slightly better and she even slept for two beautiful hours!


Thank you for letting me share my story — I would absolutely love to hear some of your travel woes! I’m sure it’s even more fun for those of you who have multiple children.


Don’t forget to follow me on Twitter @marlasok or leave your comments below!


Until next time … xo,


– Marla Sokoloff


More from Marla’s PEOPLE.com blog series:


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Lilly drug chosen for Alzheimer's prevention study


Researchers have chosen an experimental drug by Eli Lilly & Co. for a large federally funded study testing whether it's possible to prevent Alzheimer's disease in older people at high risk of developing it.


The drug, called solanezumab (sol-ah-NAYZ-uh-mab), is designed to bind to and help clear the sticky deposits that clog patients' brains.


Earlier studies found it did not help people with moderate to severe Alzheimer's but it showed some promise against milder disease. Researchers think it might work better if given before symptoms start.


"The hope is we can catch people before they decline," which can come 10 years or more after plaques first show up in the brain, said Dr. Reisa Sperling, director of the Alzheimer's center at Brigham and Women's Hospital in Boston.


She will help lead the new study, which will involve 1,000 people ages 70 to 85 whose brain scans show plaque buildup but who do not yet have any symptoms of dementia. They will get monthly infusions of solanezumab or a dummy drug for three years. The main goal will be slowing the rate of cognitive decline. The study will be done at 50 sites in the U.S. and possibly more in Canada, Australia and Europe, Sperling said.


In October, researchers said combined results from two studies of solanezumab suggested it might modestly slow mental decline, especially in patients with mild disease. Taken separately, the studies missed their main goals of significantly slowing the mind-robbing disease or improving activities of daily living.


Those results were not considered good enough to win the drug approval. So in December, Lilly said it would start another large study of it this year to try to confirm the hopeful results seen patients with mild disease. That is separate from the federal study Sperling will head.


About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.


___


Online:


Alzheimer's info: http://www.alzheimers.gov


Alzheimer's Association: http://www.alz.org


___


Follow Marilynn Marchione's coverage at http://twitter.com/MMarchioneAP


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Consumer sentiment at year low; fiscal debate weighs

NEW YORK (Reuters) - Consumer sentiment unexpectedly deteriorated for a second straight month to its lowest in over a year in January, with many consumers citing fallout from the recent "fiscal cliff" debate in Washington, a survey released on Friday showed.


The sharp drop in sentiment over the last two months coincides with rancorous federal budget negotiations that have led to higher taxes for many Americans.


Just weeks after that deal, President Barack Obama and Republican lawmakers are expected to enter another tough round of negotiations over spending cuts, which could dent consumer confidence still further.


"The handling of the fiscal cliff talks and the realization that paychecks are going to be smaller due to the sunset of the payroll tax holiday are probably weighing on consumer attitudes at the moment," said Thomas Simons, a money market economist at Jefferies & Co. in New York.


While most of the scheduled tax hikes and spending cuts forming the fiscal cliff were avoided when Congress struck a deal on January 1, most U.S. workers saw their take-home salary diminished by the expiry of two percentage-point cut in payroll taxes.


"With the debt ceiling yet to be tackled and more political acrimony on the way, we suspect that confidence has room to deteriorate further," Simons said.


The Thomson Reuters/University of Michigan's preliminary reading on the overall index of consumer sentiment came in at 71.3, down from 72.9 the month before. The index was at its lowest since December 2011. It was also below the median forecast of 75 among economists polled by Reuters.


"The most unique aspect of the early January data was that an all-time record number of consumers - 35 percent - negatively referred to the fiscal cliff negotiations," survey director Richard Curtin said in a statement.


"Importantly, the debt ceiling debate is still upcoming and could further weaken confidence," he said.


House Republicans have signaled they might support a short-term extension of U.S. borrowing authority when the government exhausts that capacity sometime between mid-February and early March. A failure by Congress to raise this debt ceiling could result in a market-rattling government default.


On Friday, Republican House Majority Leader Eric Cantor said the House would consider a bill next week to extend the debt limit by three months in order to force the Senate to pass a budget.


U.S. stocks remained little changed after the data. The S&P 500 <.spx> hit a five-year high in the last session. But on Friday, a weak outlook from Intel offset encouraging data out of China and a fourth-quarter profit at Morgan Stanley .


So far there has been a disconnect between what consumers say and do. U.S. retail sales increased a better-than-expected 0.5 percent in December. But given the recent weakening in sentiment investors will be watching for any signs that spending is starting to slip.


"The impact on consumers will be from the hike in the social security tax. That is undoubtedly going to hit discretionary spending. So this may be a signal of things to come," said Michael Woolfolk, a senior currency strategist at BNY Mellon in New York.


The consumer survey's barometer of current economic conditions fell to 84.8 from 87.0 and was below a forecast of 88.0. The gauge hit its lowest since July.


The survey's gauge of consumer expectations also slipped, hitting its lowest since November 2011 at 62.7 from 63.8, and was below an expected 65.2.


The survey's one-year inflation expectations rose to 3.4 percent from 3.2 percent, while the survey's five-to-10-year inflation outlook was unchanged at 2.9 percent.


(Additional reporting by Steven C. Johnson and Ellen Freilich; Editing by Andrea Ricci)



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Hiding, Praying, Booby-Trapped: Captives Detail Saharan Ordeal


From top left, Canal Algerie, via Associated Press; bottom right, Canal Algerie, via Reuters


Still images from Algerian television show unidentified hostages who were rescued from an Algerian gas-field complex.







The gunmen, dressed in fatigues and wearing turbans, stormed in well before dawn aboard pickup trucks, announcing their arrival with a burst of gunfire.




Dozens of employees were eating breakfast at the time before heading off to the vast network of tubes and silos of the In Amenas gas field, where hundreds of Algerians and foreigners work to extract natural gas from the arid sands of the Sahara.


“God is great,” the gunmen cried as they arrived.


It was the beginning of a terrifying ordeal — one in which foreign hostages would come under fire from both the gunmen holding them and the Algerian government soldiers trying to free them. For many of the captives, it is an ordeal that has yet to end.


Some hostages were forced to wear explosives on their bodies. Others hid under beds and on rooftops, praying to survive but expecting death. One was shot in the back while his fellow captives looked on. Left by their captors with their cellphones, some phoned home with terrifying accounts of the horrors unfolding all around.


These were among the chilling tales recounted Friday by some of the hundreds of workers who managed to escape the national gas field on the eastern edge of Algeria that had been stormed by Islamist militants two days before.


The gunmen, fighters with a group called Al Mulathameen, said they were acting to avenge the French intervention in nearby Mali, Algerian officials said. But there were indications that the attack had been planned long before the French military began its offensive to recapture the northern half of that country from Islamist insurgents.


The attackers appeared to know the site well, even the fact that disgruntled Algerian catering workers were planning a strike.


“We know you’re oppressed, we’ve come here so that you can have your rights,” the militants told Algerians at the facility, according to one Algerian former hostage. Another hostage said the fighters had asked about the plans for a strike.


“The terrorists were covered with explosives, and they had detonators,” said a senior Algerian government official briefed on the crisis. He said the situation remained a standoff on Friday, with “a few terrorists holding a few hostages.”


Former captives said that several of the fighters appeared to be foreign, with non-Algerian accents. One Algerian worker said that some of them may have been Libyan and Syrian, and that one might have been French. Another gunman who spoke impeccable English was assigned to speak to the many foreigners.


When the Algerian military eventually intervened, the situation grew even more chaotic. According to one witness, Algerian helicopters attacked several jeeps that were carrying hostages. The fate of at least some of those hostages remains unknown, as the Algerian state news agency reported that 12 Algerian and foreign workers had been killed since the start of the military operation and that dozens remained unaccounted for.


From the start, it was clear that the gunmen only wished to harm foreigners. Algerian workers, along with other Muslims who could prove their faith by reciting from the Koran, were herded into one area, workers said.


“They told us, ‘We are your brothers. You have telephones: call your families to reassure them,’ ” said Moussa, an Algerian worker who asked to be identified only by his first name.


Algerian women in the group of hostages were released right away on Wednesday morning, Moussa said, but the militants initially declined to release the Algerian men, saying it was for their own good. “We’re afraid that if we free you, the army will shoot at you,” he quoted them as saying.


Foreigners, meanwhile, were taken away, their hands bound with rubber, both Algerian witnesses said. Some of the employees resisted. Several Filipino workers who had refused to leave their rooms were beaten, Moussa said. At one point, the fighters shot a European as he tried to flee, he said. The other Algerian described seeing a middle-aged European man, perhaps a security official, shot in the back in the cafeteria, where the lights had been switched off. He believed the man had died.


Adam Nossiter contributed reporting from Bamako, Mali, and Douglas Dalby from Dublin.



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